Dapoxetine is indicated for the treatment of premature ejaculation (PE) in adult men aged 18 to 64 years. Dapoxetine should only be prescribed to patients who meet all the following criteria:
• An intravaginal ejaculatory latency time (IELT) of less than two minutes; and
• Persistent or recurrent ejaculation with minimal sexual stimulation before, on, or shortly after penetration and before the patient wishes; and
• Marked personal distress or interpersonal difficulty as a consequence of PE; and
• Poor control over ejaculation; and
• A history of premature ejaculation in the majority of intercourse attempts over the prior 6 months.
Dapoxetine should be administered only as on-demand treatment before anticipated sexual activity. Dapoxetine should not be prescribed to delay ejaculation in men who have not been diagnosed with PE
a) the control of hypertension;
b) the management of angina pectoris;
c) long term management against re-infarction after recovery from acute myocardial infarction;
d) the control of most forms of cardiac dysrhythmias;
e) the prophylaxis of migraine;
f) the management of essential tremor;
g) relief of situational anxiety and generalised anxiety symptoms, particularly those of somatic type;
h) prophylaxis of upper gastrointestinal bleeding in patients with portal hypertension and oesophageal varices;
i) the adjunctive management of thyrotoxicosis and thyrotoxic crisis;
j) management of hypertrophic obstructive cardiomyopathy;
k) management of phaeochromocytoma peri-operatively (with an alpha-blocker).
a) the control of hypertension;
b) the management of angina pectoris;
c) long term management against re-infarction after recovery from acute myocardial infarction;
d) the control of most forms of cardiac dysrhythmias;
e) the prophylaxis of migraine;
f) the management of essential tremor;
g) relief of situational anxiety and generalised anxiety symptoms, particularly those of somatic type;
h) prophylaxis of upper gastrointestinal bleeding in patients with portal hypertension and oesophageal varices;
i) the adjunctive management of thyrotoxicosis and thyrotoxic crisis;
j) management of hypertrophic obstructive cardiomyopathy;
k) management of phaeochromocytoma peri-operatively (with an alpha-blocker).
Doxycycline has been found clinically effective in the treatment of a variety of infections caused by susceptible strains of Gram-positive and Gram-negative bacteria and certain other micro-organisms.
Respiratory tract infections
Pneumonia, acute exacerbation of chronic bronchitis, sinusitis.
Urinary tract infections caused by susceptible strains of Klebsiella species, Enterobacter species, Escherichia coli, Streptococcus faecalis and other organisms.
Sexually transmitted diseases
Infections due to Chlamydia trachomatis including uncomplicated urethral, endocervical or rectal infections. Non-gonococcal urethritis caused by Ureaplasma urealyticum (T-mycoplasma). Doxycycline is also indicated in chancroid, granuloma inguinale and lymphogranuloma venereum. Doxycycline is an alternative drug in the treatment of gonorrhoea and syphilis.
Skin infections
Acne vulgaris, when antibiotic therapy is considered necessary.
Since Doxycycline is a member of the tetracycline series of antibiotics, it may be expected to be useful in the treatment of infections which respond to other tetracyclines, such as:
Ophthalmic infections
Due to susceptible strains of gonococci, staphylococci and Haemophilus influenzae. Trachoma, although the infectious agent, as judged by immunofluorescence, is not always eliminated. Inclusion conjunctivitis may be treated with oral Doxycycline alone or in combination with topical agents.
Rickettsial infections
Rocky Mountain spotted fever, typhus group, Q fever, Coxiella endocarditis and tick fevers.
Other infections
Psittacosis, brucellosis (in combination with streptomycin), cholera, bubonic plague, louse and tick-borne relapsing fever, tularaemia glanders, melioidosis, chloroquine-resistant falciparum malaria and acute intestinal amoebiasis (as an adjunct to amoebicides).
Doxycycline is an alternative drug in the treatment of leptospirosis, gas gangrene and tetanus.
Doxycycline is indicated for prophylaxis in the following conditions: Scrub typhus, travellers" diarrhoea (enterotoxigenic Escherichia coli), leptospirosis and malaria.
Prophylaxis of malaria should be used in accordance to current guidelines, as resistance is an ever-changing problem.
Consideration should be given to official guidance on the appropriate use of antibacterial agents.
Dexamethasone is a corticosteroid. It is designed for use in certain endocrine and non-endocrine disorders, in certain cases of cerebral oedema and for diagnostic testing of adrenocortical hyperfunction.
Endocrine disorders:Endocrine exophthalmos.
Non-endocrine disorders:
Dexamethasone may be used in the treatment of non-endocrine corticosteroid responsive conditions including:
Allergy and anaphylaxis: Anaphylaxis.
Arteritis collagenosis: Polymyalgia rheumatica, polyarteritis nodosa.
Haematological disorders: Haemolytic anaemia (also auto immune), leukaemia, myeloma, idiopathic thrombocytopenic purpura in adults, reticulolymphoproliferative disorders (see also under oncological disorders).
Ulcerative colitis (rectal only); regional enteritis (Crohn’s disease), certain forms of hepatitis.
Muscular disorders: Polymyositis.
Neurological disorders: Raised intra-cranial pressure secondary to cerebral tumours, acute exacerbations of multiple sclerosis.
Ocular disorders: Anterior and posterior uveitis, optic neuritis, chorioretinitis, iridocyclitis, temporal arteritis, orbital pseudotumour.
Renal disorders: Nephrotic syndrome
Pulmonary disorders: Chronic bronchial asthma, aspiration pneumonitis, chronic obstructive pulmonary disease (COPD), sarcoidosis, allergic pulmonary disease such as farmer’s and pigeon breeder’s lung, Löffler’s syndrome, cryptogenic fibrosing alveolitis.
Rheumatic disorders: some cases or specific forms (Felty’s syndrome, Sjörgen’s syndrome) of rheumatoid arthritis, including juvenile rheumatoid arthritis, acute rheumatism, lupus erythematosus disseminatus, temporal arteritis (polymyalgia rheumatica).
Skin disorders: Pemphigus vulgaris, bullous pemphigoid, erythrodermas, serious forms of erythema multiforme (Stevens-Johnson syndrome), mycosis fungoides, bullous dermatitis herpetiformis.
Oncological Disorders: lymphatic leukaemia, especially acute forms, malignant lymphoma (Hodgkin’s disease, non-Hodgkin’s lymphoma), metastasized breast cancer, hypercalcaemia as a result of bone metastasis or Kahler’s disease, Kahler’s disease.
Various: intense allergic reactions; as immunosuppressant in organ transplantation; as an adjuvant in the prevention of nausea and vomiting and in the treatment of cancer with oncolytics that have a serious emetic effect.
Treatment and prophylaxis of bleeding in patients with haemophilia A (congenital factor VIII deficiency).
Efanesoctocog Alfa can be used for all age groups.
Treatment and prophylaxis of bleeding in patients with haemophilia A (congenital factor VIII deficiency).
Efanesoctocog Alfa can be used for all age groups.
Treatment and prophylaxis of bleeding in patients with haemophilia A (congenital factor VIII deficiency).
Efanesoctocog Alfa can be used for all age groups.
Treatment and prophylaxis of bleeding in patients with haemophilia A (congenital factor VIII deficiency).
Efanesoctocog Alfa can be used for all age groups.
Treatment and prophylaxis of bleeding in patients with haemophilia A (congenital factor VIII deficiency).
Efanesoctocog Alfa can be used for all age groups.
