Drug Clinical Trials List

Study Title	Study Sponsor	Status	Study Drug	Trial Phase	Study Protocol Number	Site
EPIK-B4: A Phase II, multicenter, randomized, open-label, active-controlled study to assess the safety and efficacy of dapagliflozin + metformin XR versus metformin XR during treatment with alpelisib (BYL719) in combination with fulvestrant in participants with HR+, HER2-, advanced Breast Cancer with a PIK3CA mutation following progression on/after endocrine-based therapy	Novartis Saudi Limited	Completed	BYL719 / Alpelisib	2	CBYL719C2202	King Fahad Specialist Hospital (Dammam),King Khalid University Hospital (Riyadh)
Multinational Survey-Based Chart Review Study in International Markets to Evaluate the Effectiveness, Safety, and Treatment Patterns of DUPIXENT® (Dupilumab) in Patients with Moderate-to-Severe Atopic Dermatitis	Sanofi-Aventis group	Completed	DUPIXENT® (Dupilumab)	4	DUT0012	Specialized Medical Center (Riyadh),Dr. Erfan & Bagedo General Hospital (Jeddah)
A Phase 3, Double-blind, Randomized, Placebo-Controlled, Multicenter Study Evaluating the Efficacy and Safety of Mitapivat in Subjects With Non–Transfusion-Dependent Alpha or Beta Thalassemia (ENERGIZE)	Agios Pharmaceuticals, Inc.	Ongoing	Mitapivat	3	AG348-C-017	King Khalid University Hospital (Riyadh),King Abdulaziz Medical City NG (Riyadh),King Abdulaziz Hospital NG (Al Ahsa)
A Phase 3, Double-blind, Randomized, Placebo-Controlled, Multicenter Study Evaluating the Efficacy and Safety of Mitapivat in Subjects With Transfusion-Dependent Alpha or Beta Thalassemia (ENERGIZE-T)	Agios Pharmaceuticals, Inc.	Ongoing	Mitapivat	3	AG348-C-018	King Khalid University Hospital (Riyadh),King Abdulaziz Medical City NG (Riyadh),King Abdulaziz Hospital NG (Al Ahsa)
A Multi-Country Observational Retrospective Study to Evaluate the Prevalence of PD-L1 and its Role in Patients with TNBC Treated with Systemic Therapy (VANESSA)	Hoffmann-La Roche Ltd	Ongoing	N/A	4	MO42921	1-King Faisal Specialist Hospital and Research Center (Riyadh) Closed 2-King Abdulaziz Medical City NG (Riyadh)
A multi-centre, prospective, non-interventional single-arm study investigating clinical parameters associated with the use of once-daily oral semaglutide in a real-world adult	Novo Nordisk	Ongoing	Oral semaglutide (Rybelsus®)	4	NN9924-4542	Specialized Medical Center (Riyadh),My Clinic (Jeddah),Dallah Hospital (Riyadh),Dr. Sulaiman Al-Habib Medical Group (Riyadh),Dr. Soliman Fakeeh Hospital (Jeddah),Saudi German Hospital (Jeddah),Almoosa Hospital,Mouwasat Hospital
A Retrospective Chart Review Combined with a Prospective Cross-sectional Survey and Interviews on Patients with Type 2 Diabetes Mellitus to Assess Effectiveness of Adding SodiumGlucose Co-transporter 2 Inhibitor to Gliclazide Modified Release	ervier Affaires Médicales	Ongoing	SodiumGlucose Co-transporter 2 Inhibitor added to Gliclazide Modified Release	4	DIM-05762	King Khalid University Hospital (Riyadh),King Abdulaziz University Hospital (Jeddah),Ghassan Najeeb Pharaon hospital (Jeddah)
A Real-World Study to Assess the Disease Control of Moderate to Severe Atopic Dermatitis in Patients Receiving Dupilumab Therapy, with Atopic Dermatitis Control Tool in Gulf Countries	Sanofi	Ongoing	Dupilumab (Dupixent)	4	OBS17399	King Abdulaziz University Hospital (Jeddah),Saudi Airlines Medical Service Center,Dr. Erfan & Bagedo General Hospital (Jeddah),Specialized Medical Center (Riyadh),JC Clinics Complex – Jeddah,Saudi German Hospital (Jeddah),Sulaiman Al Habib Hospital - Al Khobar,King Fahad Medical City (Riyadh),King Faisal General Hospital (Makkah),Al Mana Hospital,King Abdul Aziz Hospital (Makkah)
A Phase 3 Open-label Trial of Neoadjuvant Trastuzumab Deruxtecan (T-DXd) Monotherapy or T-DXd followed by THP Compared to ddAC-THP in Participants with High-risk HER2-positive Early-stage Breast Cancer (DESTINY-Breast11)	Astrazeneca	Ongoing	Trastuzumab-deruxtecan	3	D967RC00001	International Medical Center (Jeddah),King Fahad Specialist Hospital (Dammam)
Evaluation Of Use of Belimumab in Clinical Practice SEttings (OBSErve): Observations from a retrospective, observational study on patients with SLE in Russia and Saudi Arabia	GSK	Ongoing	Belimumab	4	OneCDP 215	King Fahad Medical City (Riyadh),Aseer Central Hospital (Abha),King Khalid University Hospital (Riyadh),King Fahad specialized hospital (Tabuk)